摘要
对23例反复呼吸道感染小儿采用分枝杆菌多糖(MPS)系统治疗观察,检测用药前后T细胞亚群CD_4、CD_8及CD_4/CD_8之变化,并与健康对照组相比,同时进行临床疗效判断。结果患儿组治疗前CD_4及CD_4/CD_8均较对照组降低。经MPS治疗后两者均明显上升,且与健康对照组无显著差异。临床疗效判断显效和有效22例,无效1例。提示反复呼吸道感染小儿T细胞免疫功能受到抑制,MPS对改善其细胞免疫功能状态有一定作用。
cases of repeated respiratory tract infection patient were treated with MPS.20 cases of normal children were selected as control group.T-cell subgroup(CD)in peripheral blood were examined for the children of 2 groups.The effects of MPS were evaluated on the patients'clinical changes and the results of CD change.The conclusion is as follows:①The levels of CD_4 and CD_4/CD_8 in the patient group were lower than that of the normal children of control group before treatment(P<0.01),indicating that the function of cellular immunity in susceptible children in low. ②Reexamination of CD for 31 patients after treatment with MPS revealed that there is no significant difference for CD_3,CD_4,CD_4/CD_8 as compared with control group (P>0.05),indicating that MPS could improve the function for the cellular immunity of the patients. ③Clinically among 51 cases of patient,21 cases were very much improved,indicating MPS is significantly effective in the treatment of RRI and 28 cases were improved,indicating MPS is effective making a total effective rate 96% .
关键词
呼吸道感染
免疫
T细胞亚群
分枝杆菌多糖
repeated respiratory tract infection
immunity
T-cell subgroup(CD)