分枝杆菌多糖治疗小儿反复呼吸道感染的临床观察

An Observation of Mycobacterial Polysaccharides (MPS) on Treatment of Repeated Respiratory Tract infection in Children

对２３例反复呼吸道感染小儿采用分枝杆菌多糖（ＭＰＳ）系统治疗观察，检测用药前后Ｔ细胞亚群ＣＤ_４、ＣＤ_８及ＣＤ_４／ＣＤ_８之变化，并与健康对照组相比，同时进行临床疗效判断。结果患儿组治疗前ＣＤ_４及ＣＤ_４／ＣＤ_８均较对照组降低。经ＭＰＳ治疗后两者均明显上升，且与健康对照组无显著差异。临床疗效判断显效和有效２２例，无效１例。提示反复呼吸道感染小儿Ｔ细胞免疫功能受到抑制，ＭＰＳ对改善其细胞免疫功能状态有一定作用。

cases of repeated respiratory tract infection patient were treated with MPS.20 cases of normal children were selected as control group.T-cell subgroup(CD)in peripheral blood were examined for the children of 2 groups.The effects of MPS were evaluated on the patients'clinical changes and the results of CD change.The conclusion is as follows:①The levels of CD_4 and CD_4/CD_8 in the patient group were lower than that of the normal children of control group before treatment(P<0.01),indicating that the function of cellular immunity in susceptible children in low. ②Reexamination of CD for 31 patients after treatment with MPS revealed that there is no significant difference for CD_3,CD_4,CD_4/CD_8 as compared with control group (P>0.05),indicating that MPS could improve the function for the cellular immunity of the patients. ③Clinically among 51 cases of patient,21 cases were very much improved,indicating MPS is significantly effective in the treatment of RRI and 28 cases were improved,indicating MPS is effective making a total effective rate 96% .