厌食儿童补锌前后血铜、发铜、血钙、血镁水平的变化

Alterations of Serum Copper,Hair Copper,Serum Calcium and Serum magnesium Before and After Zinc Supplementation in Anorexic Children

观察203名2～7岁厌食儿童的锌、铜、钙、镁的营养状况。对其中密切合作的147人进行补锌后的纵向观察,旨在探讨锌与钙、镁、铜之间可能存在的相互关系,找出适宜的服锌量。结果表明:补锌前厌食组儿童的血铜低于对照组(P<0.05),发铜有低的趋势;厌食组血锌、发锌水平较低时相应的血铜、发铜有较高的趋势,反之亦然。经单相关分析,发锌与血铜、发铜呈负相关(P<0.05)。补锌后血锌、发锌增加的同时,血铜明显降低,发铜降低不显著。为避免发生铜缺乏,建议日服锌总量小于20mg。补锌前厌食组儿童的血镁低于对照组(P<0.01),血钙有低的趋势,血钙、镁与血锌、发锌无相关关系。补锌后血钙上升(P<0.05),血镁上升不显著。

A comprehensive evaluation of zinc,copper,calcium,and magnesium status wasconducted in 203 children with anorexia aged 2-7 years,147 of whom took 3-7 mg ofzinc sulfate/kg/day for two months.The purposes of the study were to explore therelationship between zinc and copper,calcium as well as magnesium,to determinethe proper dose of zinc sulfate.The results showed that serum copper content of children with anorexia wassignificantly lower than that of the normal control and there was no significant dif-ference in hair copper contents between the two groups.Hair zinc level correlatedinversely with copper levels in serum and hair of the children with anorexia.Thecontent of serum copper dropped significantly after zinc treatment,but still withinnormal range.To prevent copper deficiency,a dose below 20 mg/day was suggested.Serum magnesium content in 203 children with anorexia was lower than that ofthe control and there was no significant difference in serum calcium level betweenthe two groups.There were no correlations between zinc content in serum or hairand calcium or magnesium content in serum.Serum calcium level increased markedlyafter zinc supplementation.