预激综合征患者保护性药物治疗的临床疗效与药物电生理效应观察—无创性方法学研究及应用评价

Electrophysiologic Effect and Clinical Resuit of Protective Drug Administration in Patients with WPW Syndrome:Noninvasive Methodologic Study and Evaluation of Application

对12例有阵发性心动过速发作史的 WPW 患者进行了保护性药物治疗前后的无创性电生理研究。6例正路前传型 AVRT 患者应用乙胺碘呋酮后,APERP 轻度延长。3例正路逆传 AVRT 患者在应用安搏律定或普鲁卡因酰胺后 APERP 明显延长。上述9例患者用药后心动过速不能被诱发或不能维持。3例 AF 或 Af 的患者服用乙胺碘呋酮或普鲁卡因酰胺后,2例不能诱发,另1例能诱发 AF,但无心室预激。上述12例患者在保护性药物治疗后,临床上大多无心动过速发作。本文表明,特别是对有危险的 WPW 患者,保护性药物治疗的临床疗效与电生理效应是一致的。因此,这一方法是进行药物筛选的一种理想的无创性技术。

Noninvasive electrophysiologic study was performed before and after drug admi-nistration in 12 patients with WPW who had paroxysmal tachycardia.6 patients hadinduction of orthodromic atrioventricular reciprocating tachycardia(AVRT).Theaccesory pathway effective refractory period was increased slightly after amioda-tone.3 patients had induction of antidromic AVRT,the APERP was significantly in-creased after apridine or procainamide.The above mentioned 9 patients lost the abi-lity to induce or sustain AVRT after administration of the drugs.2 of other 3 pa-tients with AF or Af had no induction of arrhythmia,1 had it but without WPWafter amiodarone or procainamide.Most of all 12 patients had no clinically tachy-cardia.In patients with WPW syndrome especially those with high-risk,electrophysiologicefficiency of administration of protective drugs is coincided with clinical efficaoy.Therefore the method is a desirable noninvasive technique in screening drugs.