口服避孕药对动脉粥样硬化影响的实验研究

Experimental Study on Effects of Oral Contraceptives on Arteriosclerosis

本文应用形态学观察,同位素技术以及血清中血小板聚集比,α,β-脂蛋白的测定,探讨了口服避孕药Ⅰ号对家兔动脉粥样硬化的影响。实验结果表明:口服避孕药Ⅰ号可轻度抑制主动脉粥样硬化,但对冠状动脉病变和心肌坏死的发生率有轻度促进作用,并可明显使其病变程度加重。口服避孕药Ⅰ号使血小板聚集比较对照组略有增强,这与其对冠状动脉的影胸一致,与某些临床和实验资料报道一致。本实验结果支持口服避孕药对心脏的不良影响是由孕酮成分所引起的观点。

The effect of oral Contraceptive I on experimental atherosclerosis of rabbits havebeen observed and studied by first using several combined morphologic and functionalmetabolic indices,especially by the two kinds of coordinative isotope;tecjmoqie ofautoradiography and liquid scintillation.The results showed that oral Contraceptive I might slightly restrain atherogene-sis but had a slight promotion of the incldence of coronary atherosclerosis and myo-cardionecrosis and caused the lesion more serious in comparison with the controls.By comparison,the platelet aggregation might be increased by Contraceptive I,whichcorresponded with certain clinical and experimental reports.This experiment suppor-ted the idea that the adverse effects of oral Contraccptive I on cardiovascular sys-tem were attributed to progesterone ingredient in the drug.