实验性糖尿病的内分泌、主动脉改变及维生素E的影响

Endocrinal Aortic Changes in Experimental Diabetes and Effect of Vitamin E

将20只日本大耳白纯种白兔分成两组,一组为维生素 E 组,另一组为对照组,每组包括10只白兔,所有白兔(20只)均静脉注射 Alloxan 140mg/kg,然后依下列时间每组各取一只进行取血检查血糖、血果糖胺、脂质、胰岛素、T_3、T_4及解剖检查胰岛、甲状腺、主动脉等。时间是注射前、注射后第1、3、7、14、28天及第1月、2月、4月、8月。维生素 E 不能防止胰岛 B 细胞坏死及血清胰岛素的降低,因此,它未能阻止高血糖及果糖胺的升高。维生素 E 不能明显降低血胆固醇。维生素 E 可以降低甘油三酯,但不十分显著。维生素 E 可以提高高密度脂蛋白-胆固醇,因此,它可以减轻动脉粥样硬化病变。T_4降低是属于适应性反应。维生素 E 对之无作用。

Twenty Japan white rabbits were divided into 2 groups,the group of vitaminE and the control group,with 10 rabbits in each group.Alloxan 140mg/kg were in-travenously injected into all rabbits.Then,blood sugar,lipids,HDL-C,insulin,T_sand T_4 were determined and biopsies of the pancreas thyroid and aorta done beforeinjection,and on the 1st,3rd,7th,14th day,Ist month,2nd month,4th month and8th month after injection.Vitamin E could not prevent the B islet cell from necrosis and a decrease ofserum insulin.Hence,it could not prevent hyperglycemia and hyperfructosamine.Vitamin E could not decrease plasma cholesterol but could decrease triglyceridesthough not markedly.Vitamin E could increase plasma HDL-C and might be helpfulin case of atherosclerosis.The decrease of T,was a response in which Vitamin Ehas no effect.