雌二醇对实验性动脉粥样硬化影响的形态学和自显影研究

Morphologic and Autoradiographic Studies of Effect of Estradiol onExperimental Atherosclerosis

本文利用病理组织学、超微结构、生化学和同位素技术研究了雌二醇对实验性动脉粥样硬化的影响和作用机理。结果表明:雌二醇通过抑制因高脂血症而致的内皮通透性增强,防止了~3H-胆固醇向动脉内膜的渗入;另外抑制动脉平滑肌细胞增生和血小板聚集,从而有明显预防粥样斑块形成的作用。

The effect of estradiol on experimental atherosclerosis was studied by usingmainly morphological,biochemical and autoradiographic techniques.The results showed that estradiol markedly prevented atheroma formation inthe aorta and coronary arteries.~3H-cholestrol autoradiography and scintillation coun-ting indicated that estradiol had the inhibitory effect on the increase of endothe-lial permeability induced by hypercholesterolemia.The early lesions under electronmicroscope were also consistent with the above results.It was shown that estradiolcould inhibit proliferation of aortic smooth muscle cells and obviously restrainedplatelet aggregation,both were mechanisms in prevention of atherosclerosis.Lowlevel of total serum cholesterol and triglyceride in the experimental group suggestedthat inhibitory effects of estradiol on atherogenesis might also be concerned withthe changes of serum lipids but the exact relationship between them was relativelycomplicated and remained to be investigated.