慢性小管间质性肾炎——18例临床分析

Clinical Tubulointerstitial Nephritis——Clinical Analysis of 18 Cases

本文报告18例慢性小管间质性肾炎,并分析其临床与实验室资料,结果表明感染与药物损伤为本病的主要原因,本病的突出临床表现是由于肾脏的浓缩与酸化功能障碍,常表现为多尿多饮及肾小管性酸中毒并伴有氮质血症、骨营养不良及贫血。文中讨论了慢性 TIN 的发病机制及临床诊断指标,认为虽无病理组织学资料,而凭临床资料亦能作出诊断。

Eighteen patients of chronic tubulointerstitial nephritis were reported with theclinical and experimental data analized.The results showed that infection and drugdamage might be the main causes of CTIN.The prominent clinical features of thesecases were due to disturbance of renal concentration and acidification ability usuallymanifestating polyuria,polydipsia and renal tubular acidosis accompanied by azote-mia,osteodystrophy and anemia.The pathogenesis and clinical diagnostic criteria ofCTIN were discussed.It was suggested that diagnosis could be established by meansof clinical data though in lack of histopathogical evidences.