有家族史肝癌的病因、病理及预后(附76例报告)

Etiology,Pathology and Prognosis of Liver Cancer Patients with Familial Histories——Report of 76 Cases

原发性肝癌被视为多基因遗传病,同时,又是多种因素共同作用的产物。为探讨其遗传病因、病理形态及其预后方面的特征,本文将本所手术的152例病例,均分有、无家族史两组进行分析比较。结果显示,肝癌家族聚集现象和高发家族的存在;有家族史组患病高峰年龄提前,患者发病年龄偏低;乙型肝炎病毒感染率和肝炎曾患率明显高于对照组;病理形态除肿瘤大小、瘤栓多少及肿瘤部位等项外,其它数项无显著差异;术后一、三、五年生存率对照组似比有家族史组为好。

Primary liver cancer was seen as a hereditary disease of multiple genes,and also-was a product which were caused by combination of many factors.152 resected pa-tients were divided into two groups by with familial history or without familialhistory(control).The result showed that(1)familial aggregation of hepatocarcinomawas present;(2)the great majority of patients in the group of familial history wereyounger than those without familial history;(3)infective rate of HBV and incidenceof hepatitis in the group with familial history were significantly higher than thosein the control group;(4)except the size,location of tumors and numbers of canceremboli,others were not significantly different in pathology and gross morphologybetween two group;(5)survival rates of 1,3,5 years in the group of familial historyesemed lower than those in the control group.