红细胞葡萄糖6磷酸脱氢酶缺陷与糖尿病关系初探

A STUDY OF THE ASSOCIATION OF G6PD DEFICIENCY WITH DIABETES MILLITUS

对１５６例（男１０１，女５５）糖尿病患者作了红细胞葡萄糖６磷酸脱氢酶Ｇ６ＰＤ活性测定，结果表明：男性糖尿病组Ｇ６ＰＤ活性（１２．０８±３．６２ＮＢＴ单位），较对照组（１３．４４±３．６５ＮＢＴ单位）低，差异有高度显著性（Ｐ＜０．００５）；女性糖尿病组（１２．３２±３．６１ＮＢＴ单位）也较对照组（１３．９８±３．８７ＮＢＴ单位）低，差异显著（Ｐ＜０．０１），糖尿病病人Ｇ６ＰＤ活性低于正常值下限７．６９（Ｘ－１．６４５Ｓ）者男性组的发生率（１１．８％）较对照组（３．４％）高，差异显著（Ｐ＜０．０１）；女性组的发生率也有升高趋势。

RBC G6PD activities of 156 patients(m 101,f 55) suffering from diabetes millitus were investigated,showing that the G6PD activity of male patients(12.08±3.62NBTU) was lower than that of the normal controls(13.44 ±3.65NBTU) and the difference being highly signific ant(P<0.005) while that of female patieuts was also lower than that of the normal and the difference being significant( P<0.01),and that in terms of diabetesG6PD activity which is lower than the low limit 7.69( X-1.645S) the prevalence rate of the disease in the male group(11.8%) is higher than that of the normal(3.4%) and the difference being markedly significant( P<0.01);in the female group the prevalence rate also har an increasing tendency.