恶性淋巴瘤患者及其一级亲属染色体不稳定性、脆性部位的研究

THE STUDY OF CHROMOSOMAL ABERRATION RATES AND FRAGILE SITES IN PATIENTS WITH MALIGNANT LYMPHOMAS AND THEIR FIRST ─ DEGREE RELATIVES

采用低叶酸培养基对２４例恶性淋巴瘤患者和２０例患者的一级亲属染色体不稳定性、脆性部位进行研究，发现两组的染色体畸变率和脆性部位表达均显著高于正常对照，并且脆性部位３ｐ~１４、１１ｑ~１３、６ｐ~２２、１２ｑ~１３表达显著增高，提示两组的染色体不稳定性增高及这些特异的脆性部位可能与恶性淋巴瘤遗传易感性有关。

The chromosomal aberration rate (including gap and break) and expression frequency of common fragile sites were examined in peripheral blood lymphocytes cultured with TC199 medium from 24 patients with malignant lymphoma and 20 of their first-degree relatives. And 26 normal subjects were used as control. Both the chromosomal aberration rates and expression frequencies of common fragile sites observed in patients and their relatives were significantly higher than those of control subjects. The expression of fra(11) (q13 ) and fra (6) (p22) were more frequently observed,and the mean frequencies of their expression in patients and their relatives were significantly higher than in control subjects.