钙离子对维生素K3镇痛作用的影响

Effect of Ca2+ on Anaigesic Action of Vitanin K3

本文研究Ｃａ２＋对ＶｉｔＫ３镇痛作用的影响．在小白鼠辐射热甩尾模型上Ｖｉｔｋ３（６４ｍｇ／ｋｇ，ｉｐ）’：有明显的镇痛作用（Ｐ＜０．０１），这种作用能被ＣａＣＩ２（１．０Ｘ１０－７ｍｏｌ，ｉｃｖ）拮抗（Ｐ＜０．０５），被Ｃａ２＋络合剂ＥＧＴＡ（５．２６×１０－７ｍｏｌ ／ｋｇ， ｉｃｖ）和Ｃａ２＋通道阻滞剂维拉帕米２５ｍｇ／ｋｇ，ｉｃｖ）增强（Ｐ值接近０．０５）。结果提示，细胞内外Ｃａ２＋浓度影响ＶｉｔＫ３的镇痛作用．

y means of the tail flick test in mice,the offect of Ca+ on analgesic action of vitamin Ks wasStudied. The results showed that each of vitamin K3(64mg/kg,iP).Ca2+ chelating agent EGTA(5. 26X 10-7vmol/kg, icv) and ca2+ channel blocker verapamil (0. 25mg/kg,icv) possessed analgesic action(P<0.01 respectively), that CaCl2 (1. 0 X 10-7mol/kg, icv) reduced the analgesic action of vitamin k3<p0.01), while both EGTA and verapamil did not enhanced the analgesic action of vitamin K3signifcantly. The results suggest that the intracellular and Ca2+ concentration can Producean effect on the analgesic action of vitamin K3.