灼伤病人外周血IL—6、TNF的水平与休克相互关系的研究 

Study of the Relation Between Circulatng IL-- 6.TNF Levels and shock in Burn Patients

采用Ｂ９细胞增殖的ＭＴＴ法及Ｌ９２９细胞结晶紫比法，对１０例Ⅱ度以上的灼伤病人检测４个不同时期外周血ＩＬ—６、ＴＮＦ含量。结果表明，正常人血清中ＩＬ—６、ＴＮＦ含量＜１０ｋＵ／Ｌ（１２例），与灼伤病人区别明显（Ｐ＜０．０１）。灼伤病人外周血ＩＬ—６、ＴＮＦ的水平与灼伤的面积、严重程度、临床分型以及休克发生发展有密切的相关性，而ＩＬ—６、ＴＮＦ含量变化早于休克的发生，其变化有良好的规律性．提示外周血ＩＬ—６、ＴＮＦ含量变化可作为判断灼伤休克的一个指标。

sing a modified growth assay of IL-- 6--depedet Bg Cells and TNF cytotoxicity of L929 cells.We investignted the circulating levels of IL-- 6,TNF in 1 0 petients with over--second--degree burnsat the fourth stase. Experimental results indicated that the IL -- 6, TNF levels in burn patientsremarkably increased compared with that in normal donors(P<0. o1). Which varies with the burninjrUty degree, Clinical claSSification and. shOCk attaCk. IntereStedy the inCenSe of iL -- 6, TNFcirculating levels appears earlier than clinical shock sign. Therefore tracing the changes of serums IL6 and TNF in burn patients will be very useful for the Prognostic of burn shock.