摘要
采用石蜡切片免疫组化法，测定了４８例胃癌组织中雌激素受体的分布。结果阳性者１７例，阳性率３５．４％；同时测定１２例非肿瘤性胃粘膜（慢性炎症及胃溃疡）作为对照，结果仅１例阳性（８．３％），两者之间有明显差异（Ｐ＜０．０１）。各年龄组及性别间差异均无统计学意义。将胃癌分成分化型及未分化型（包括印戒细胞癌）两组，结果显示未分化型癌的阳性率（６１．５％）比分化型者（１８．２％）明显增高（Ｐ＜０．０ｌ）。表示雌激素在癌的发生、发展中有明显的刺激作用，癌细胞的生长及恶性度对雌激素有一定依赖性。临床上应用内分泌疗法对雌激素受体阳性肿瘤进行辅助治疗是行之有效的。
Estrogen Receptor of 48 cases Gastric Carcinoma was detected bvParaffin section and immunochemistric method.The results showed that:There were17 positive cases(35. 4%);There was only l in non tumour gastric deseases,there wasobviously difference(P<0.01).The positive rate of high degree carcinoma was higherthat of low degree(P<0. 0l).Therefore,ER may make carcinoma to progress. Therewas a wonderful curative effect on positive ER by endocrinotherapy.
出处
《泰山医学院学报》
1994年第3期168-170,共3页
Journal of Taishan Medical College
关键词
雌激素受体
内分泌疗法
胃肿瘤
gastric carcinoma
Estrogenic Receptor
endocrinotherapy
