摘要
给小鼠一次性腹注Ｄ－胺基半乳糖（Ｄ－Ｇａｌｎ）６００和１２００ｍｇ／ｋｇ，或１６小时内连续６次腹注３００ｍｇ／ｋｇ，停药后４８小时，血清谷丙转氨酶（ＳＧＰＴ）明显升高，局部肝细胞呈现肝炎病理形态改变。病变机理是过量Ｄ－Ｇａｌｎ入肝代替了尿苷二磷酸葡萄糖的代谢途径所引起的。
The mice injected D-galactosamine(D-Galn) ince 600 and 1200 mg per kiro of body weight in adominal cavity,or it should be injected once 300mg and continuous 6 time in 16 hours.After 48 hours showed notable elevation of SGPT.local cells of liver induced pathomorphological change with hepatitis.Pathogenesis were due to D-Galn substitute for uridine diphosphoglucose(UDPG) way of metabolism.
关键词
胺基半乳糖
小白鼠
损肝机理
D-galactosamine Hepatodegeneration Liver injuries mechanism SGPT
