高血压、冠心病及合并糖尿病患者血浆甘丙素浓度的临床初步观察

Plasma Galanin Concentration in Patients with Hypertension Coronary Heart Disease and both Complicated by Diabetes Mellitus

用放免法检测31例原发性高血压、冠心病及冠心病合并糖尿病和高血压患者(CHDMH)血浆甘丙素水平。结果显示:病人组均高于对照组。其中以冠心病合并糖尿病和高血压组浓度最高(9.18±6.05pmol/L),单纯冠心病组最低(3.22±0.98pmol/L),高血压病组居中(5.04±1.51pmol/L)。上述各组除单纯冠心病组外,与对照组之间经t或F-Q检验均有显著差异(P<0.01)。各组血浆甘丙素水平与年龄之间相关性检验无显著意义。

In cases of essential hypertension (EH)?coronary heart disease (CHD) and diabetes mellitus (DM) diagnosed with criteria of WHO, the plasma contents of galanin were determined by radioimmunoassy. The results shoved quite more significant in- crease(5.26= 0.74 pmol/L)of galanin in all patients than those in the control (2.98 = 1.56 pmol/L, t= 9.903,P<0.001). In particular, in patients with CHD accompanying DM and EH, their plasma level of galanin (9.18 ±6.05 pmol/L,Q= 20.10, P<0.01, vs other groups) was the highest among all groups, in patients with CHD (3.22 ± 0.98 pmol/L), the level was more less than any other group, and in patients with EH (5.05 ± 1.51 pmol/L) the level laid in between the groups above mentioned. It is possible that the galanin would be related with the origin and development of those diseases.