肺心病患者血LPO、GSH、SeGSH-Px水平及动态观察

Dynamical Observation of Levels of LPO, GSH, SeGSH Px in Blood in Patients with Chronic Cor Pulmonale

测定肺心病患者急性发作期血中LPO、GSH含量升高,SeGSH-Px含量降低,与正常组对照差异显著。对27例肺心病患者的血LPO、GSH、SeGSH-Px进行动态观察,结果表明急性期血LPO含量明显高于缓解期,缓解期血SeGSH-Px含量明显高于急性期,提示可用这三项指标监测肺心病病情转化。回归方程提示肺心病患者血LPO、GSH、SeGSH-Px含量与肺心病分期、血pH和Hb含量有高度相关性。

In our study, levels of LPO and GSH were higher in blood in patients with cor pulmonale, inverse SeGSH-Px was lower than those of control group. Dynamical observation of 27 cases with cor pulmonale showed that the level of LPO was obviously higher in acute phase than in relax phase, and the level of SeGSH-Px was significantly lower in relax phase than in acute phase. These levels may be used to moni-ter the clinical changes of cor pulmonale. Analysis of multiple stepwise regression showed that there were high correlations between the levels of LPO, GSH, SeGSH-Px and the various phase, pH value, hemoglobin content.