胃安素对大鼠慢性实验性胃溃疡愈合的影响

Effect of Thymic Protein on Healing of Chronic Experimental Gastic Ulcer in Rats

用不同剂量的胃安素(胸腺蛋白,TP)治疗大鼠慢性实验性胃溃疡。结果:1.TP_1(10mg·kg^(-1)·d^(-1)),TP_2(15mg·kg^(-1)·d^(-1))组大鼠溃疡面在喂药10天后均缩小,与盐水对照组比较,分别有高度显著性(P<0.01)和显著性差异(P<0.05),TP_1与TP_2两组面积比较有显著性差异(P<0.05);2.喂药20天大鼠胃溃疡完全愈合率比较:TP_1(75.0％)>TP_2(50.0％),高剂量的TP_3(50mg.kg^(-1)·d^(-1))组无效,其愈合率(5.0％)低于盐水对照组(15.0％);胃安素与西咪替丁联合应用效果最佳,其愈合率(94.47％)与对照组(15％,P<0.05)及西咪替丁组(55.0％,P<0.05)比较具有显著性差异。结果表明,一定剂量的胃安素能促进大鼠慢性实验性胃溃疡的愈合,与西咪替丁合用能更有效地提高溃疡的治愈率。

In our laboratory, we used the thymus extracts (thymic protein, TP) with different dosage and cimetidine to deal with chronic experimental gastric ulcer in rats. The results: 1. By given oral administration -of TP for 10 days, the ulcer area of the rats in both TP1 (10mg·kg-1d-1) and TP2 (15mg·kg-1d-1) treatment groups had been reduced, with very significant (P<0.01) and significant difference (P<0.05) compared with that in the control respectively! and with the significant difference (P<0.05) between the two groups (TP1 vs TP2). 2. Complete recovery rate comparison after 20 days of treatment: TP1 (75.0%)>TP2 (50.0%), the recovery rate (5%) in TP3 group with high dosage (50mg·kg-1d-1) is lower than that in the control (15.0%); The effect of the combined therapy of TPt with cimetidine was the best, its recovery rate (94.47%) was significantly higher than that of the control (F<0.05) and the cimetidine group (55.0%, P<0.05). Thus, TP with certain dosage can promote the healing and recovery rate of the chronic experimental gastric ulcer in rats, and the effect may be enhanced by its combining usage with cimetidine.