女性膀胱癌X染色质出现率意义初探

Significance of Barr Body Frequency in Bladder Cancer in Women

对63例膀胱癌和13例正常膀胱粘膜上皮进行X染色质(X chromatin,通常以Barrbody表示)出现率(BBF)进行观测。结果:BBF在正常膀胱粘膜上皮与Ⅱ、Ⅲ级膀胱癌间差异有极显著性,在有无肿瘤转移复发间的差异有高度显著性;在5年生存与5年死亡组间差异亦有极显著性。提示BBF愈低,肿瘤的分化程度愈差,生物学行为愈恶劣(BBF在45％以上无转移复发,30％以下出现转移复发)。BBF降到20％为危险信号(BBF<20％的病例5年内均死于膀胱癌,BBF>34％的病例5年生存率为100％)。

Study on the X chromatin as Barr body frequency (BBF) in 63 cases of woman's bladder cancer had been carried out with 13 cases of normal bladder epithelium as control. The results revealed that the differences of X chromatin frequency between 3 different grading bladder cancers, between tumors with metastasis and that without metastasis, and between patients of five year death and those still living in five years had statistical significance. The results showed that the X chromatin frequency decreased with less differentiation of the tumor and with worse prognosis of the case. It was proposed that the decrease of BBF to or below 20% may be a signal of worse prognosis, that was hazardous to death within 5 years.