丙型肝炎患者血清流行病学及临床特征(附124例报告)

The Seroepidemiology and Clinical Characters of 124 Cases with Hepatitis C

对124例HC住院患者血清流行病学和临床特征进行分析,探讨天津地区HC的流行和发病特点及其意义。结果输血后HC的发病率为66.1％,说明血源传播在我国同样是HCV传播的重要途径,提示血液筛查对防止HC的传播意义重大。本组病例临床表现病程长,多数ALT、BiL轻～中度升高。AH占58.06％,值得注意的是CH及LH占35.48％,提示HCV感染具有明显的慢性化趋势。重叠感染的65例中60例合并HBV感染,与单纯HC59例相比ALT反跳、BiL水平及病程持续时间均有显著性和非常显著性差异,分别<0.05,P<0.01和P<0.01。提示重叠感染,病毒协同作用加重肝损伤。

To analyse the seroepidemiology and clinical characters of 124 cases with hepatitis C in Tianjin area. Most Patients (66.1%) had a transfusion history, it suggested that transfusion of infected blood or blood products was the important way of HCV transmission in China, and screening of blood donors played an important role in prevention. In addition, there were slight or mild rises in serum ALT and Bil levels, the course was long. About 35.45% of the Patients became chronic carriers. There were 60/124 patients being HCV and HBV co-infections, 59/124 had only HCV infections. The superinfected patients had most severe symptoms.