乙型慢活肝血清SOD与GST测定的临床意义

Clinical Significance of Serum SOD and GST Levels in Patients with Chronic Active Hepatitis B

分别测定30例正常人及34例乙型慢活肝活动期及静止期的SOD、MnSOD、MDA及GST的血清含量。结果慢活肝活动期与正常人及静止期病人比较均有显著差异,说明乙型慢活肝病人的SOD、MnSOD、MDA的血清含量,与病情严重程度一致。血清GST活性与SOD有明显相关性,显示了GST在反应肝细胞损伤程度上的敏感性。

Serum levels of superoxide dismutase (SOD), MnSOD, MDA and glutathione stransferase (GST) were measured in 30 healthy people and 34 cases with chronic hepatitis B, including active and inactive cases. The serum levels in patients with chronic active hepatitis B were significantly different from those in either healthy people or inactive patients. It was indicated thatserum SOD, MnSOD and MDA were related to severity of the chronic hepatitis B. The serum GST was markedly correlated with SOD and it was sensitive to reflect hepato-cellular damage.