吸烟者肺泡壁细胞构成

Cellularity of the Alveolar Walls in Smokers

36例吸烟肺分为:无肺气肿组(NE)9例。小叶中央型肺气肿组(CLE)14例,全小叶型肺气肿组(PLE)13例。应用图象分析系统测量随机肺泡壁和小气道周围肺泡壁细胞数(Cells/mm)和嗜中性白细胞数(PMN/mm),并评估小气道炎症。结果显示:吸烟者随机肺泡壁Cells/mm明显高于非吸烟者(P<0.0001);吸烟肺三组的Cells/mm无明显区别(NE:47.7±6.7;CLE:48.9±7.6;PLE:49.5±4.6),然而CLE的细胞分布极不均一,并在小气道周围占优势,明显不同于PLE和NE(均P<0.01)。CLE小气道炎症与肺泡壁Cells/mm明显相关(r=0.75,P<0.01),而PLE无这种关系;PMN/mm仅占总细胞的3％～5％,各例间无明显区别。总之,吸烟肺细胞构成的特点与肺破坏的类型有密切关系。

The smokers' lungs of 36 cases were divided histologically into 3 groups: no emphysema (NE) 9 cases, centrilobular emphysema (CLE) 14 cases, and panlobular empoysema (PLE) 13 cases. Cells/mm and PMN/mm in random alveolar walls (RW) and alveolar waMs around small airway (AW) were measured by image analysis system. The results showed that RW-cells/mm was significantly -higher in smokers than in nonsmokers (P<0.0001); there was no significant difference in RW-cells/mm in the 3 groups of smokers' lungs (NE: 47.7±6, 7; CLE: 48.9±7.6; PLE; 49.5±4.6), however, the cell distribution was very .uneven and predominant around the airways in CLE, and significantly different than in PLE and NE (P<0.01 for all). The marked correlation between small airway inflammation score and RW-cells/mm was shown in CLE (r = 0.75, P<0.01), but not in PLE; PMNs were presented between 3% and 5% of all cells and it was similar in all cases. In summary, the pattern of hypercellularity in smokers' lungs follows the oattern of lung destruction.