再灌注对急性心肌梗塞犬左室收缩功能影响的实验研究

Influence of Reperfusion on Left Ventricular Systolic Function in Canine Model of Acute Myocardial Infarction

利用结扎犬冠状动脉左前降支及实施血流再灌注的方法对20只急性心肌梗塞犬不同时间的血流动力学指标进行了观察,并将再灌注与非再灌注犬心脏功能的变化进行了对比。结果发现冠状动脉左前降支结扎以后2小时、3小时和72小时心排血量较梗塞前降低,肺楔压明显升高,梗塞后72小时再灌注组心排量高于非再灌注组,肺楔压低于非再灌注组,说明再灌注可明显改善急性心肌梗塞犬心功能。

The hemodynamic changes of 20 canine models of acute myocardial infarction established by ligation and reperfusion of left anterior discending branch of coronary artery were observed. The differences of heart function between reper-fusion and non-reperfusion group were compared. The results showed that cardiac outputs were lower and pulmonary capillary wedge pressures were higher in 2, 3 and 72 hours after ligation of coronary artery than those before ligation. The cardiac outputs were higher and pulmonary capillary wedge pressures were lower in reperfusion group than those in non-reperfusion group in 72 hours after acute myo-cardial infarction. This suggested that heart function of dogs after acute myocar-dial infarction could be improved by reperfusion.