期刊文献+

连环蛋白与恶性肿瘤 被引量:2

下载PDF
导出
摘要 连环蛋白(catenin,cats)是细胞信号转导分子和黏附分子,参与由E钙粘蛋白(E-cadherin,E-cad)介导的细胞内信号转导,在细胞黏附、生长、增殖和细胞转归过程中起重要作用。全文对连环蛋白家族四种类别(α,β,γ-cat和p120ctn)的结构、生物学特性逐一介绍,并分别阐述它们与恶性肿瘤(结直肠癌、肝癌、肾癌、胃癌、胰腺癌等)生物学行为的关系。
出处 《医学信息(西安上半月)》 2005年第3期276-279,共4页 Medical Information
  • 相关文献

参考文献34

  • 1Christofori G, Semb H, et al. The role of the cell adhesion molecule E-cadherin as a tumour suppressor gene [J].Trends Biochem Sci, 1999,24:73-76.
  • 2Hinck L,NathkeiS,PapkotfJ, et al. Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways[J]. J Cell Biol, 1994,125:1327-1340.
  • 3Dillon DA, Aquila T, Reynolds AB,et al. The expression of pl20ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin[J]. Am J Pathol, 1998,152(1):75-82.
  • 4Chen WC,Obrink C,et al. Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells[J].J Cell Biol 1991,114:319-327.
  • 5Shimoyama Y,Nagafuchi A,Fujita S,et al. Cadherin dysfunction in human cancer celline:possible involvement of loss of α -catenin expression in reduced cell-cell adhesiveness [J]. Cancer Res, 1992,52:5770-5777.
  • 6Ernesto Resnik,et al. beta-Catenin--one player, two games. Nature Genetics, 1997,16:9-11.
  • 7Cowin P, Kapprell HP, Franke WW,et al. The complement of desmosomal plaque proteins in different cell types [J].J Cell Biol,1985,101:1442.
  • 8Lewis JE, Wahl JK 3rd, Sass KM, eta 1. Cross-talk between adherens junctions and desmosomes depends on plakoglobin [J].J Cellboil, 1997,136:91913.
  • 9Rosato R,Veltmat JN, Groffen J, et al. Involvement of the tyrosine kinase fer in cell adhesion [J]. Mol Cell Biol, 1998,18:5762-5770.
  • 10]Thoreson MA, Anastasiadis PZ,Daniel JM, et al. Selective uncoupling of p120 (ctn) from E-cadherin disrupts strong adhesion[J]. J Cell Biol, 2000,148:189-201.

同被引文献13

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部