RNA干扰——治疗HIV感染的新方法
摘要
RNA干扰 (RNAi)是由双链RNA介导的 ,特异性沉默内源或外源性同源基因的过程。RNAi的分子生物学特征当前已被用于抗HIV感染和治疗AIDS病。本文就RNAi抗HIV机制和近两年来RNAi在抗HIV 1感染方面的最新研究进展及在RNAi实验设计上需注意的问题等方面加以综述。
出处
《国外医学（病毒学分册）》
2005年第1期5-8,共4页
Foreign Medical Sciences(Section of Virology)
参考文献21
-
1Lee NS, Dohjima T, Bauer G, Li H, Li MJ, Ehsani A et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol, 2002, 20(5) :500-505.
-
2Stein P, Svoboda P, Anger M, Schultz RM. RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase. RNA,2003, 9(2) :187-192.
-
3Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD.Asymmetry in the assembly of the RNAi enzyme complex. Cell,2003, 115(2) :199-208.
-
4Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature, 2002, 418(6896) :435-438.
-
5Hu WY, Myers CP, Kilzer JM, Pfaff SL, Bushman FD. Inhibition of retroviral pathogenesis by RNA interference. Curr Biol, 2002, 12(15): 1301-1311.
-
6Vickers TA, Koo S, Bennett CF, Crooke ST, Dean NM, Baker BF. Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis. J Biol Chem, 2003, 278(9) :7108-7118.
-
7Brisibe EA, Okada N, Mizukami H, Okuyama H, Fujii YR. RNA interference: potentials for the prevention of HIV infections and the challenges ahead. Trends Biotechnol, 2003, 21 (7): 306-311.
-
8Coburn GA, Cullen BR. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J Virol, 2002, 76(18) :9225-9231.
-
9Park WS, Hayafune M, Miyano-Kurosaki N, Takaku H. Specific HIV-1 env gene silencing by small interfering RNAS in human peripheral blood mononuclear cells. Gene Ther, 2003, 10(24) :2046-2050.
-
10Garrus JE, von Schwedler UK, Pornillos OW, Morham SG,Zavitz KH, Wang HE et al. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell, 2001, 107(1) :55-65.
-
1温韬.白介素—12抗HIV感染的研究进展[J].传染病网络动态,2003(6):39-42.
-
2温韬,吴昊.白细胞介素-12及其在抗HIV感染中的研究进展[J].国外医学（流行病学．传染病学分册）,2003,30(5):271-274. 被引量：4
-
3徐冰.增强HIV疫苗接种免疫应答的新方法[J].国际生物制品学杂志,2006,29(3):116-116. 被引量：1
-
4张石革,龙振华.蛋白酶抑制剂的市场诱惑与在抗HIV感染中的应用评价[J].中国医药导刊,2003,5(4):284-287. 被引量：1
-
5刘成龙,初荣,吴尊友,Roger Detels.人类白细胞抗原与抗HIV感染之间的遗传关系[J].中国艾滋病性病,2003,9(6):392-393.
-
6陈琳,邵建国.RNAi技术在胰腺癌中的应用[J].国际消化病杂志,2007,27(6):418-419.
-
7多价抗CCR5核酶抗HIV感染基因治疗切实可行[J].传染病网络动态,2001(6):25-25.
-
8相洪琴.可增强免疫细胞抗HIV感染的两种化合物[J].国外医学情报,2005,26(9):20-20.
-
9张人参,刘光明.HIV感染的分子诊断与治疗[J].旅行医学科学,1998,4(4):54-54.
-
10李平,熊瑛.RNA干扰与呼吸系统疾病的治疗[J].医学综述,2009,15(22):3392-3394.
