螺旋藻多糖和鼠尾藻多糖对四氧嘧啶致糖尿病大鼠血管的保护作用

Protective effects of polysacchride of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan induced diabetic rats

目的研究螺旋藻粗提多糖和鼠尾藻粗提多糖联合使用对四氧嘧啶糖尿病大鼠血管的保护作用。方法2种多糖以1∶1混合,分别以123,368,1103mg·kg-1灌胃给予四氧嘧啶致高血糖大鼠高、中、低各组。连续给药6周后,分别测定各组大鼠的血糖、TC,HDLC,TG,NO,ET。并取各鼠胸主动脉测定其对去甲肾上腺素(NE)和乙酰胆碱(ACh)舒缩反应的变化。结果混合多糖能降低ALX性糖尿病大鼠的血糖与血清TC,TG,NO,ET,升高血清HDLC。ALX模型大鼠主动脉对NE的收缩反应显著增强,对ACh舒张反应显著减弱。混合多糖能显著降低NE的收缩反应,改善糖尿病大鼠血管内皮依赖的舒缩反应功能。结论2种多糖联合使用能降低血糖并对血管有一定的保护作用。

Objective: To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergiion vascular of alloxan (ALX) induced diabetic rats. Method: With the doses of polysaccharide of Spirulina platensis(PSP) and Sargassum thunbeergii(PST) compound(1∶1) 12.261, 36.783,110.349 mg·kg^-1 by ig administration to alloxan induced diabetic ratsrespectively for 6 weeks. Then the blood glucose and the TC, HDL-C,TG, NO,ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabetic rats has been studied. Result: The results showed the compound of PSP and PST could decrease the blood glucose and the TC,TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabetic rats. The contraction responses to NE in aortic rings of the alloxan induced diabetic rats weresignificantly elevate in the normal rats, and the responses to ACh weresignificantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabetic rats. Conclusion: PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabetic rats. [