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Ryanodine受体结构、功能的病变与心力衰竭及药物治疗 被引量：5

Altered Structure and Function of Ryanodine Receptor in Heart Failure as well as Its Drug Treatment
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摘要 Ryanodine受体与心肌兴奋收缩偶联有着密切的关系 ,近年来已成为心力衰竭治疗的又一新靶点 ,对其的研究也日趋深入。对Ryanodine受体的结构和主要功能 ,Ryanodine受体的生理及药物调节 ,衰竭心脏中Ryanodine受体结构与功能的病变进行阐述 ,并简要概述针对Ryanodine受体病变的心力衰竭的药物治疗。 Ryanodine receptor plays an important role in excitation-contraction coupling. The structure and function of ryanodine receptor, regulation, and its changes on structure and function in heart failure were illuminated in this article. Moreover, the drug treatment related to Ryanodine receptor was summarized.
作者 张媛 戴德哉
机构地区 中国药科大学药理研究室
出处 《药学进展》 CAS 2005年第2期49-56,共8页 Progress in Pharmaceutical Sciences
基金 国家自然科学基金重点资助项目 (30 2 30 1 70 30 1 71 0 78)
关键词 RYANODINE受体 兴奋收缩偶联 心力衰竭 Ryanodine receptor Excitation-contraction coupling Heart failure
分类号 R541.6 [医药卫生—心血管疾病]
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药学进展
2005年 第2期

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