3-[1-羟基-2,6,6-三甲基-4,4-(乙二氧基)-2-环己烯基]丙炔醇的合成及其稳定性研究

Synthesis and stability research of 3-( 1-hydroxy-2, 6, 6-trimethyl-4,4-ethylenedioxo-hex-2-eiie) propynol

报道了标题化合物的合成,并针对与该化合物稳定性相关的因素进行了系统的分析研究,确定了其不稳定性主要表现在缩酮部位的水解;建立了用1HNMR的方法跟踪监测该化合物的动态变化,该化合物及其分解后产物的结构都经过1HNMR进行了确证。

In this paper, the synthesis of 3-(1-hydroxy-2, 6, 6-trimethyl-4,4-ethylenedioxo-hex-2-ene) propynol.a key intermediate in the synthesis of abscisic acid analogues, was reported. The decomposition process was determined by 1HNMR and the main course was proved to be the hydrolysis of the ketal moiety.