硝苯啶对小儿左向右分流型先天性心脏病的急性血流动力学效应

The Acute Hemodynamic Effects of Nifedipine in Children with Left-to-right Shunt Congenital Heart Diseases

在右心导管检查时，对21例左向右分流型先天性心脏病患儿舌下含化硝苯啶（nifedipine）的急性血流动力学效应进行观测。结果表明，基础状态下外周血管阻力（SVR）增高、肺循环血流量（QP）明显增加而体循环血流量（Qs）显著减少的中量到大量左向右分流型先天性心脏病患儿，舌下含化硝苯啶有减低SVR、增加Qs和降低Qp/Qs比值的作用，从而可减少左向右分流里。

We evaluated the acute hemodynamic response to nifedipine during diagnostic cardiac catheterization in 21 patients,aged 1.5 to 12.6 years,with left-to-right shunt con-genital heart diseases.It was showed that nifedipine had a beneficial effect on patients with middle to large left-to-right shunt ongenital heart diseases.It reduced the left to right shunts and increased he systemic blood flow.These effects were not seen in patients with small left-to-right shunt congenital heart diseases.