壳聚糖-阿拉伯胶布洛芬缓释微囊制备工艺研究

Study on the Preparation Technology of Ibuprofen-chitosanSustained Release Microcapsule

本文以壳聚糖和阿拉伯胶为囊材 ,利用复凝聚法将布洛芬微囊化。以微囊的药物包封率为制备工艺优化指标 ,通过正交实验得出微囊的最佳制备工艺条件为 :壳聚糖浓度为 0. 2 %、成囊pH为 4. 5、成囊温度为 4 5℃、搅拌速度为 2 0 0rpm。以最佳制备工艺条件制备含药微囊 ,重现性好 ,工艺稳定 ,同时体外溶出实验表明 ,该微囊具有较好的缓释作用。

A complex coacervation method was used to prepare Ibuprofen microcapsule using chitosan and Gum-arabic as the wall materials .The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules.The result show that pH=4.5,C(chitosan )=0.2 %,v=200 rpm,T=45 ℃ are the best technology.The vitro release of the microcapsules indicate that these microcapsules may prove better sustained release of drugs.