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^(99)Tc^m-AnnexinV用于体内细胞凋亡显像的研究进展 被引量：1

Advance of apoptosis imaging with ^(99)Tc^m labeled Annexin V
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摘要 细胞凋亡早期,磷脂酰丝氨酸从细胞膜脂双层的内层迁移至外层,利用99Tcm标记的AnnexinV对细胞凋亡暴露在细胞膜表面的磷脂酰丝氨酸进行体内显像,可检测早期细胞凋亡。 Phosphatidyl serine exposures on the outer leaflet of the plasma membrane lipid bilayer at the beginning of apoptosis, 99Tcm-labeled Annexin V is used to image in vivo the phosphatidyl serine that explode on the outer surface of cell membrane after apoptosis so that apoptosis can be detected on the early stage.
作者 靳彩玲 范我
机构地区 苏州大学放射医学与公共卫生学院
出处 《国外医学（放射医学核医学分册）》 2005年第1期23-26,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 ^99Tc^m-Annexin V 细胞凋亡 核素显像 Tcm-Annexin V apoptosis radionuclide imaging
分类号 R817 [医药卫生—影像医学与核医学]
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参考文献15

  • 1Kemerink GJ, Boersma HH, Thimister PML, et al. Biodistribution and dosimetry of ^99mTc -R BTAP-R Annexin V in human[J]. Eur J Nuel Med, 2001, 28(9): 1373-1378.
  • 2Tokita N, Hasegawa S, Maruyama K, et al. ^99mTc-R HYNIC-R Annexin V imaging to evaluate inflammation and apoptosis in rats with autoinunune myocarditis [J]. Eur J Nucl Med Mol Imaging, 2003, 30(Suppl 2): S139.
  • 3Kemerink GJ, Liu X, Kieffer D, et al. Safety, biodistribution, and dosimetry of ^99mTc-R HYNIC-R Annexin V, a novel human recombinant Annexin V for human application[J]. J Nuel Med, 2003,44(6): 947-952.
  • 4Zhu L, Liu BL, Guo YZ. Tc-R 99m direct labeling of Annexin V for potential apoptosis imaging in vivo [J]. J Labelled Cpd Radiopharm, 2003, 46(Suppl 1): S324.
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  • 8Blankenberg FG, Katsikis PD, Tait JF, et al. In vivo detection and imaging of phosphatidylsefine expression during programmed cell death[J]. Proc Nail Acad Sci USA, 1998, 95(11): 6349-6354.
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同被引文献8

  • 1左强,张军一,陈锦章,罗荣城.^(131)I标记抗CD20单克隆抗体在荷瘤裸鼠体内的放射免疫显像[J].肿瘤防治研究,2007,34(7):473-476. 被引量：3
  • 2Ly Tran,Baars J W,Maessen H L,et al.A simple and safe method for 131I radiolabeling of Rituximab for myeloablative high-dose radioimmunotherapy[J].Cancer Biother Radiopharma,2009,24(1):103-110.
  • 3Oriuchi N,Higuchi T,Endo K,et al.Application of 18F-FDG PET for the assessment of early response to the treatment and prognosis of patients[J].Kaku Igaku,2009,46(2):96-99.
  • 4Takei T,Kuge Y,Zhao S,et al.Enhanced apoptotic reaction correlates with suppressed tumor glucose utilization after cytotoxic chemotherapy:use of 99mTc-Annexin V,18F-FDG,and histologic evaluation[J].J Nucl Med.2005,46(5):794-799.
  • 5Chen Y,SALD M,Endo C,et a1.Expression of Bcl-2,Bax and p53 proteins in carcinogenesis of squamous cell lung cancer[J].Anticancer Res,1999,19(2B):1351-6.
  • 6Blankenberg F G,Katsikis P D,Tait J F,et al.Imaging of apoptosis (programmed cell death) with 99mTc-R Annexin V[J].J Nucl Med,1999,40(1):184-191.
  • 7郑玉民,王自正,杨翔,华子春,王峰,方纬,孟庆乐,范我.^(99)Tc^m-Annexin V衍生物的制备及其生物分布和凋亡显像[J].中华核医学杂志,2007,27(5):288-291. 被引量：5
  • 8蔡秋琼,杜明华,陈宝安,钟英,黄科,屈海船.^(131)I-Rituximab对B细胞淋巴瘤生物学效应的实验研究[J].东南大学学报（医学版）,2008,27(3):157-160. 被引量：1

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国外医学（放射医学核医学分册）
2005年 第1期

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