摘要
帕金森病是发生于中年以上的中枢神经系统的变性疾病,由于多巴胺产生不足,引起多巴胺D2受体功能异常。Raclopride(雷氯必利)对中枢神经系统D2受体具有高度的选择性和亲和力,是研究D2受体分布的理想示踪剂。11C-raclopridePET可在分子水平直观地显示D2受体的分布、密度及变化情况,对帕金森病的病情分析、序列运动的多巴胺机制分析、运动波动合并症的机制分析、药物作用机制分析、外科治疗的机制分析等方面具有重要意义。
Parkinson's disease( PD ) is a kind of degenerative disease afflicting middle-aged and older people, accompanied by abnormal D2 receptor function resulted from dopamine deficiency. Raclopride is an ideal tracer because of its high selectivity and affinity to D2 receptor. 11C-raclopride PET can directly show the distribution and density of D2 receptor on molecular level that it's of great importance in the analysis of the illness state and dopamine mechanism of sequential movement, movement-fluctuation complication, medicine and surgical therapy.
出处
《国外医学（放射医学核医学分册）》
2005年第1期27-29,共3页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
