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酸性神经鞘磷脂酶的生物学特性及其功能 被引量：3

Property and function of acid sphingomyelinase
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摘要 神经鞘磷脂酶(SMase)可水解鞘磷脂产生神经酰胺,在人体内发挥重要作用。酸性神经鞘磷脂酶(ASMase)作为SMase最重要的一个亚型,在辐射诱导细胞凋亡、调节肿瘤细胞生长、参与Fas信号系统传递等方面均可发挥重要作用。 Sphingomyelinase can hydrolyze the sphingomyelin to ceramide. And sphingomyelinase play important roles in diverse physiological. Acid sphingomyelinase is the most important type of sphin-gomyelinase.
作者 侯丽莉 陈肖华
机构地区 军事医学科学院放射医学研究所
出处 《国外医学（放射医学核医学分册）》 2005年第1期44-47,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 神经鞘磷脂酶 酸性神经鞘磷脂酶 神经酰胺 凋亡 sphingomyelinase acid sphingomyelinase ceramide apoptosis.
分类号 Q55 [生物学—生物化学]
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参考文献16

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同被引文献40

  • 1倪韶青,寿洪初,赵正言,曾苏,王珏.谷胱甘肽硫-转移酶与疾病和化疗[J].中国药学杂志,2005,40(20):1530-1533. 被引量：6
  • 2郭海霞,薛红漫,夏焱,徐令,徐宏贵,李文益.siRNA对VEGFR_2的表达抑制及对HL60细胞和人内皮细胞的影响[J].中山大学学报（医学科学版）,2006,27(3):276-280. 被引量：4
  • 3彭萍,杨冬梓,莫亚勤,郑澄宇,罗璐,张清学.1-磷酸-神经鞘氨醇预防化疗大鼠卵巢功能损害的实验研究[J].中山大学学报（医学科学版）,2007,28(1):15-18. 被引量：12
  • 4高军,周灿权,张仁礼,马芸.靶向SMPD1基因的RNA干扰对人成纤维细胞凋亡的保护作用[J].中山大学学报（医学科学版）,2007,28(2):159-164. 被引量：3
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  • 8Paris F, Gloria I, Fuks Z, et al. Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring, a letter to the editor[J]. Nat Med, 2002, 8(9):901-902.
  • 9Tuschl T. Functional genomics: RNA sets the standard[J]. Nature, 2003,421(6920) :220-221.
  • 10Tilly JL, Kolesnick RN. Sphingolipids, apoptosis, cancer treatments and the ovary; investigating a crime against female fertility [J]. Biochim Biophys Acta, 2002,1585(2-3): 135-358.

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国外医学（放射医学核医学分册）
2005年 第1期

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