福辛普利联合美托洛尔治疗慢性心力衰竭疗效观察

Therapeutic Effects of the Combination of Fosinpril and Metoprolol on Patients with Congestive Heart Failure

目的:探讨福辛普利联合美托洛尔治疗慢性心力衰竭(CHF)的安全性和远期临床疗效。方法:122例CHF患者(男性93例,女性29例),平均年龄(59.19±12.52)岁,随机分成两组。治疗组63例给予福辛普利5-40 mg/d,美托洛尔12.5-100 mg/d,对照组59例给予美托洛尔12.5-100 mg/d。两组基础治疗雷同,疗程12个月。观察治疗前后两组患者的临床症状, 心功能分级,超声心动图心功能指标,6 min步行距离的变化及不良反应。结果:平均随访时间12个月,治疗组和对照组的安全性和耐受性均良好。治疗组临床总有效率为88.89%,对照组总有效率为76.27%,两组治疗前后相比左室射血分数(LVEF)、6 min步行距离均有显著的改善(P<0.01)。治疗组LVEF、6 min步行距离的改善优于对照组。结论:福辛普利联合美托洛尔治疗CHF安全有效,可以增强疗效,明显改善远期预后。

Objective: To explore the safety and long-term clinical outcome of the combination of fosinpril and metoprolol on patients with congestive heart failure(CHF). Methods: 122 patients with CHF were studied prospectively there was 93 males and, 29 females, average age was 59. 19 ± 09:02 05-6-10 12. 52 years. They were randomly divided into two groups: 63 patients (therapeutic group) were treated with combination of Fosinopril (5-40 mg/d) and Metoprolol (12. 5-100 mg/d) ;59 patients (control group) were treated with Metoprolol (12. 5-100 mg/d). The basic therapies were same in both groups. Following-up and the continuous therapeutic period were 12 months. Clinical symptoms,classification of cardiac function,the index of echocardiography changes of 6 minute walk distance,adverse effects were observed before and after treatment in two groups. Results: All the patients in two groups were well tolerated and there were no adverse effects shown up within 12 months' following-up. The effective rate was 88. 89% in therapeutic group and 76. 27% in control group. The left ventricular ejection fraction (LVEF)and changes of 6 minute walk distance were obviously improved after treatment in two groups (P<0. 01 .respectively). Conclusion:It is a safe and effective method to treat CHF patients with the combination of Fosinopril and Metoprolol. It can improve the longterm prognosis obviously.