机械通气患者营养状况和免疫功能的变化及生长激素对其的影响

Changes of nutritional status and immunological function in patients with mechanical ventilation and the effects of recombinant human growth hormone

目的 观察机械通气患者的营养状况和免疫功能变化以及重组人生长激素 (rhGH)对其治疗作用。方法 36例机械通气患者随机分为试验组 (rhGH组 ) 17例 ,对照组 19例 ,两组患者的营养支持方案相同 ,试验组予以rhGH 8U/d ,连续7d。观察两组患者各营养指标和免疫指标的变化结果。结果 两组患者治疗前营养状况和细胞免疫指标均低于正常。治疗3d后 ,试验组转为正氮平衡 (P <0 .0 5 ) ,同时前蛋白增加显著 (P <0 .0 1) ,CD3、CD4、CD8、CD4 /CD8比值增加明显 (P <0 .0 5 ) ;治疗 7d后 ,rhGH组血清蛋白和免疫指标较对照组改善明显 (P <0 .0 5 ,P <0 .0 1)。结论 营养支持联合rhGH能进一步改善机械通气患者的营养状况 ,同时对机体的免疫功能也有更好的调理作用。

Objective To investigate the changes of nutritional status and immunological function in patients with mechanical ventilation and the effects of recombinant human growth hormone(rhGH).Methods 36 patients with mechanical ventilation were divided randomly into control group(19 cases) and test group(rhGH,17cases),Patients in test group were given rhGH 8 U/d for 7 days. The indexes of nutritional status and immunological function were recorded and compared between two groups. Results The nutritional status of two groups decreased in all the patients, and so did the activity of CD3,CD4,CD8,NK and the ratio of CD4/CD8. The levels of serum prealbumin and the activity of CD3,CD4,CD8,NK and the ratio of CD4/CD8 increased significantly in rhGH group at 3day compared the control group ( P <0 05, P <0.01).Conclusion The combination of nutrition support with rhGH improves the nutritional status and immunological function in patients with mechanical ventilation.