眼结膜印迹细胞法(CIC)与血清VitA浓度测定法的比较研究

Comparative study of conjunctival impression cytology (CIC) with serum vitamin A concentration assay method.

目的:确定眼结膜印迹细胞法(CIC法)用于儿童群体亚临床Vit A缺乏(SVAD)早期筛查的可行性.方法:采用CIC法,对438例3～7岁学龄前儿童进行Vit A营养状况评价,评价结果与血清Vit A水平相比较.结果:①随着血清VitA水平的降低结膜印迹细胞异常程度也相应增加(P＜0.05),两者的符合率为93.17%.②有26.38%(110/410)的研究对象结膜印迹细胞出现异常改变,提示CIC法可以早期发现SVAD.结论:CIC法是一种能够有效地评价儿童机体Vit A营养状况,早期发现SVAD的快捷方法.

Objective:To determine the feasibility of conjunctival impression cytology (CIC) used in the early screening of children with subclinical vitamin A deficiency (SVAD).Methods:With CIC method, the nutrition status of 438 children aged 3~7 years old were evaluated and compared with serum vitamin A concentration.Results:① With the levels of serum vitamin A decreased, the abnormal degree of CIC increased accordingly (P<0.05).The coincidence rate of two methods was 93.17%.② The abnormal rate of CIC was 26.83%, which suggested CIC method could detect early subclinical vitamin A deficiency.Conclusion:CIC is a quick and objective method for effective assessment of vitamin A status of children and early detection on SVAD.