摘要
目的探讨清开灵注射液抗大肠埃希菌O111B4内毒素作用。方法采用细菌内毒素检查法(体外)和兔热原检查法(体内),对清开灵注射液抗细菌内毒素作用进行实验。结果清开灵注射液稀释16倍可使浓度为10EU·mL1等体积的内毒素破坏;兔静脉注射清开灵注射液(2mL·kg1)后注射细菌内毒素40EU·kg1引起轻度发热反应(Tmax=035℃),而未给清开灵注射液组呈现典型的发热反应(平均Tmax=105℃)。结论清开灵注射液有抗大肠埃希菌内毒素作用。
Objective To study the effect of qingkailing(QKL) injection in counteraction of E. Coli O_~111 B_~4 endotoxin. Method The anti-endotoxin effect of QKL injection were studied by determination of bacterial endotoxin and by pyrogen test in rabbits. Results Even if being diluted for 16 mutiples, QKL injection could destroy equal volume of endotoxin (10 EU·mL^-1 ). When the endotoxin injection was administered by iv following QKL (2 mL·kg^-1 ), only a slight fever was induced in the rabbits while obvious fever presented in the group without receiving QKL injection. Conclusion QKL injection had the effect counteracting endotoxin of E.Coli O_~111 B_~4 .
出处
《医药导报》
CAS
2005年第3期185-186,共2页
Herald of Medicine
关键词
清开灵注射液
细菌内毒素
细菌内毒素检查法
热原检查法
Qingkailing injection
Bacterial endotoxin
Bacterial endotoxin determination
Pyrogen test
