卡前列素氨丁三醇在中央性前置胎盘剖宫产时应用时间的探讨及疗效

Evaluation of application time and effects of carboprost trometamol for patient with complete placenta praevia in cesarean-section

目的:探讨卡前列素氨丁三醇在中央性前置胎盘孕妇剖宫产时的应用时间及疗效.方法:38例中央性前置胎盘孕妇分成2组,研究组26例,年龄(27±s4)a,剖宫产胎儿娩出后予宫体和静脉分别注射缩宫素各20 U,宫缩仍不佳即宫体注射卡前列素氨丁三醇0.25 mg;对照组12例,年龄(31±4)a,剖宫产胎儿娩出后予宫体和静脉注射缩宫素各20 U,宫缩仍不佳再继续应用缩宫素20～50 U,宫缩仍不佳才予宫体注射卡前列素氨丁三醇0.25 mg.结果:研究组术中出血量非常明显低于对照组[(471±240)mLvs(746±339)mL,P＜0.01];而2组产妇术后2 h内出血量,差异无显著意义(P＞0.05).结论:中央性前置胎盘剖宫产时,应用缩宫素40U后宫缩不佳即应改用卡前列素氨丁三醇,疗效较好.

AIM: To explore the application time and effect of carboprost trometamol on bleeding of complete placenta praevia in cesarean-section. METHODS: According to the opportunity of applying carboprost trometamol, 38 parturients were divided into study group (n=26; age (27±s 4) a) and control group (n=12; age (31±4) a). The study group was treated with carboprost tromethamine 0.25 mg if uterine contraction was poor after applying oxytocin 20 U for uterus and intravenous injection of each. The control group was also treated with oxytocin 20-50 U due to poor uterine contraction after applying oxytocin 20 U for each of the uterus and intravenous injection and if uterine contraction was still poor and then followed by applicotion carboprost trometamol 0.25 mg. RESULTS: The blood loss in study group was lower than that in the control group ((471±240) mL vs (746±339) mL,P< 0.01). There was no significant difference of the amount of bleeding within 2 h after cesarean section between the two groups(P> 0.05). CONCLUSION: Carboprost trometamol should be applied if uterine contraction is poor after applying oxytocin 40 U in cesarean-section of complete placenta praevia.