阿魏酸钠对急性期脑梗塞病人血浆血栓素B_2、6-酮-前列腺素F_(1α)及血清脂质过氧化物的影响

The Effect of Sodium Ferulate on TXB_2,and Lipid Peroxide in Patients with Acute Cerebral Infarction

对60例急性期脑梗塞病人血浆血栓素B_2（TXB_2）、6-酮-前列腺素F_(1α)（6－Keto－PGF_(1α)）和血清脂质过氧化物（LPO）水平变化以及阿魏酸钠（SF）对其影响研究。结果发现，急性期脑梗塞病人LPO水平显著升高并持续2周以上，6-Keto-PGF_(1α)与LP0呈负相关,SF对TXB_2有显著抑制作用（P＜0.O1），而对6-Keto-PGF_(1α)无明显影响。SF对LPO的抑制作用明显优于维生素E（P＜0.01），其机理可能与SF对自氧化和酶促过氧化均产生抑制作用有关。

60 patients with Acute Cerebral Infarction were randomizedly divided into three groups.Control group was administred intravenously 10％ Dextran 500 ml daily.An equal amount of Dextran was used in the two other groups.Sodium feruate (SF) group plus Vitamin E 300mg daily.The results show that serum lipid peroxide (LPO) levels were sig nificantly higher than normal levels (P＜O.01 ).Significant negative linear correlations were noted between LPO and 6-Keto-PGF_(1α+).SF significantly inhibeted plasma TXB_2 leves (P＜0.01) with out affecting 6-Keto-PGF_(1α)levels.Serum LPO levels were significantly decreased in the SF group.The mechanism of SF may lie in that it prevents both auto-oxidation and enzyme-processing peroxidation in vivo.