异氟醚复合拉贝洛尔控制性降压在颅脑手术中的应用

Deliberated Hypotension with Isoflurane Plus Labetalol in Neurosurgical Patients

对24例择期颅脑手术病人采用异氟醚复合拉贝洛尔控制性降压，并与单纯用异氟醚降压者进行了对比观察。病人随机分成单纯异氟醚降压组（Ⅰ组）和异氟醚复合拉贝洛尔降压组（Ⅱ组），每组12例。结果显示，降压时Ⅱ组呼气末异氟醚浓度明显低于Ⅰ组（P＜O.01），血流动力学改变较Ⅰ组轻。由此认为，异氟醚复合拉贝洛尔控制性降压用于颅脑手术可能优于单纯异氟醚降压。

24 patients who required deliberated hypotension for neurosurgical operations were studied in order to investigate the effects of labetalol on isoflurane-induced hypoten sion.24 ASA Ⅰ—Ⅱ patients undergoing elective cerebral surgery were randomly divided in to 2 groups (n=12 each),group Ⅰ (isoflurane alone) and group Ⅱ (isoflurane plus la betalol).The results showed that in group Ⅱ end tidal concentration of isoflurane was lower and hemodynamic changes were slighter than that in group Ⅰ during hypotension.It suggest that use of isoflurane plus labetalol may be more favorable than use of isoflurane alone for neurosurgical patients during hypotension.