NIDDM病人血浆组织型纤溶酶原激活物及其抑制物的活性水平与胰岛素抵抗关系的探讨

The Relationship of Tissue Plasminogen Activator and Inhibitor Activity Levels with Insulin Resistance in NIDDM Patient

测定了33例非胰岛素依赖型糖尿病(NIDDM)病人血浆组织型纤溶酶原激活物(t-PA)及其抑制物(PAI)的活性水平，发现其t-PA水平降低而PAI水平增高，t-PA与PAI呈负相关，PAI水平与空腹血浆胰岛素(FPI)、体重指数(BMI)、甘油三酯(TG)呈正相关，与空腹血浆葡萄糖／空腹血浆胰岛素比(FPG／FPI)、面积血浆葡萄糖／面积血浆胰岛素比(APG／API)呈负相关，与腰围、臀围之比(WHR)及糖尿病(DM)微血管病变无显著相关性。提示了“胰岛素抵抗─PAI增高─动脉粥样硬化”之间，可能存在着规律性的内在联系。

The activity levels of plasma tissue plasminogen activator(t-PA)and plas-minogen activator.inhibitor(PAI)were observed in 33 patients with non-insulin-dependent diabetes mellitus(NIDDM).The results showed that t-PA level was increased with the de-crease of PAI.PAI level was positively related to fast plasma insulin,body mass index (BMI),triglyceride(TG),but was negatively related to fast plasma glucose／fast plasma in-sulin ratio and area plasma glucose／area plasma insulin ratio.PAI showed no significant cor-relation with waist-hip circumference ratio(WHR)and microangiopathy of DM.It was sug-gested that there might be a relation among insulin resistance,elevation of PAI and atherosclerosis.