一种中西药复方制剂(PESM)对大鼠实验性肾结石形成的抑制作用

The Inhibition of Experimental Renal Calculus by Chinese-Western Medicine Compound Preparation(PESM)in Rats

用乙二醇法诱导大鼠产生草酸钙结石，用＾４５Ｃａ示踪测定法了解中草药复方制剂（ＰＥＳＭ）对草酸钙结石形成的抑制作用。结果显示，实验组肾脏放射性强度明显减少（实验组３．４７±３．５２ｃｐｍ／ｍｇ，对照组１０．８９±１４．２４ｃｐｍ／ｍｇ）。干肾重量明显下降（实验组３０６．０±４７．０ｍｇ，对照组３４３．１±５９．４ｍｇ），说明ＰＥＳＭ能明显抑制肾脏草酸钙结石的形成。

We studied the inhibitory effect of a Chinese-Western medicine compound preparation(PESM)on lithogenesis of calcium oxalate calculus by45~Ca tracing determination in rats with renal calcium oxalate calculus induced by ethylene glycol.The results showed that the radioactive intensity in the experimental group was 3.47±3.52 cpm／ml,and in the control group the intensity was 10.89±14.24cpm／ml.The weight of dried kidney was markedly decreased,in the experimental group the weight was 306.0±47.00mg,and was 343.1±59.4mg in control group.This experiment demonstrated that the PESM can obviously inhibit the lithogenesis of calcium oxalate calculus in kidney.