活血化瘀方对被动吸烟孕鼠红细胞膜Ca^(2+)-ATP酶活性的影响

Effect of Huoxuequyu Recipe on Erythrocyte Membrane Ca^(2+)－ATPase Activity in Pregnant Rats Receiving Passive Smoking

以被动吸烟致胎儿宫内发育延缓（IUGR）大鼠为模型，观察了活血化瘀方对孕鼠红细胞膜Ca^(2+)－ATP酶活性的影响。结果表明：模型组胎仔出生平均体重、Ca^（2+）-ATP酶活力均低于对照组（P＜0.01），用药组与对照组之间差异无显著意义（P＞0.05），且胎仔平均出生体重与Ca^(2+)-ATP酶活性呈正相关关系（r=0.3446,P＜O.05）。从而提示本方能提高Ca^(2+)-ATP酶活性，保护红细胞正常形态与功能,从而改善胎盘血液循环，促进胎儿发育。

The effect of Huoxuequyu recipe on erythrocyte membrane Ca^(2+)-ATPase ac tivity in pregnant rats with passive-smoking-induced asymmetrical intrauterine growth retar dation(IUGR) was observed.The rats were devided into three groups:control group,mod el group and treated group.The fetal mean birth weight and erythrocyte membrane Ca^(2+)-ATPase activity Were found to be decreased in mode1 group as copared with control and treated group.There was a significant difference between model and control group(P〈0.01),while insignificant difference existed between treated and control grouP(P＞0.05)．The fidings indicated that the erythrocyte membrane Ca^(2+)-ATPase activity seems to have a strict positive correlaion with the birth weighi(P＜0.05).Thus,it is likely that there is a connection between increased red cells Ca^(2+)-ATPase activity and improved blood circula tion.The Huoxuequyu decoction has a benificial effect on the fetal development．