心肌代谢显像剂^（123）I－HDA制备方法的改进

A MODIFIED METHoD FOR PREP ARATIoN OF ￣(123)I-HDA

￣（１２３）Ｉ标记的十七烷酸￣（１７－１２３）Ｉ－ＨｅｐｔａｄｅｃａｎｏｉｃＡｃｉｄ，简称￣（１２３）Ｉ－ＨＤＡ）是一种较常用的脂肪酸（ＦＦＡ）类心肌代谢显像剂，核医学临床用于评价心肌能量代谢。介绍一种改进的￣（１２３）Ｉ－ＨＤＡ制备方法，使制备过程缩短至９０ｍｉｎ，总放射性回收率≈７０％，可得到放射化学纯度＞９９％的无载体、无前体￣（１２３）Ｉ－ＨＤＡ注射液，较目前常用的其它注射液制备方法更适合于临床常规应用。

A modified method for preparation of￣(123)I-Heptadecanoic acid(￣(123)I-HDA )is described.The la-belling yield is 92.8%(n=32, 85%一97%)by heating time of 15 minutes.The overall recovery isabout 70%.The time for the whole preparation is about 90 min.The method described is reliable,convenient,a carrier free and precursor free preduct of high purity in a reasonable short time.