^3H—柔红霉素—白蛋白药物微球在大鼠肝内的分布

THE DISTRIBUTION OF ￣(3)H-D-HAMS IN RAT LIVER

用放射性自显影及放射性测定方法显示经大鼠肝门静脉注入￣３Ｈ－Ｄａｕ－ＨＡＭＳ后，￣３Ｈ－Ｄａｕ在肝脏中的沉积量为腹腔注射￣（３）Ｈ－Ｄａｕ的数十至数百倍，且滞留时间明显延长，并有微球栓塞引起的肝组织坏死及再生现象，表明药物微球栓塞及增效的双重作用。

By means of autoradiographic and radioactivity counting metheds,it is shown that￣(3)H-Dau re-tained in rat liver is significantly higher(tens to hundreds times)and longer by route of intraportal in-jection of ￣(3)H- Dau-HAMS than by intraporitoneal injection of ￣(3)H- Dau,and there are morphologicalchanges of nectosis induced by microsphere embolization and sutbsequent regeneration. The resuIts indi-cate that chemotherapeutic microspheres might play a dual role of embolization and therapeutic enhance-ment effects.