幽门弯曲菌与胃部疾病关系的探讨

A Study of Relationship Between Campylobacter Pyloredis and Gastro-duedenal Diseases

对113例因上消化道症状而进行胃镜检查的患者,采用胃粘膜活检标本直接涂片染色后查找幽门弯曲菌(CP)。结果各种胃部疾病患者CP检出总阳性率为62.8％(71/113),其中慢性浅表性胃炎、慢性萎缩性胃炎、胃溃疡、十二指肠球部溃疡分别为77.5％(31/40)、65.2％(15/23)、64.3％(9/14)及72.2％(13/18),与正常组比较差异均非常显著(P<0.01)。活动性慢性胃炎的CP检出阳性率显著高于非活动性慢性胃炎(P<0.05)。提示CP感染与慢性胃炎和消化性溃疡的发生有一定的因果关系。

Biopsy samples were taken from the gastric mucosa of 113 patients who were investigated for upper gastro-intestinal symptoms by endoscoby. Totally, 71 of the 113(62.8％)cases were positive for Campylobacter pyloridis(CP): 31 of the 40 (77.50％)patients with chronic superficial gastritis, 15 of the 23(65.2％)with chronic atrophic gastritis, and 9 of the s4(6.4.3％)with gastric ulcer werepositive for CP, but CP was isolatcdin only 2 of the 10 (20.0％) patients withgastric carcinoma and in 1 of the 8 (12.5％) histologically normal cases. The significant association between the presence of CP and chronic gastritis as well as peptic ulcer was noted and the positive rate of CP well correlated with the activity of chronic gastritis. CP is suggested to be etiologically associated with chronic gastritis and peptic ulceration.