软腭癌放射治疗的预后因素分析

Prognostic factors of soft palate cancer treated with definitive radiotheraphy

目的 :探讨影响软腭癌放射治疗的预后因素。方法 :1990年 1月至 1999年 7月我科收治的软腭癌患者 90例 ,男性 63例 ,女性 2 7例。鳞癌 48例 ,低分化癌 2 2例 ,未分化癌 12例 ,腺癌 8例。采用直线加速器外照射 ,照射剂量 60～ 70GY/6～ 7W。用Kaplan -Meier法计算生存率和局部控制率 ,Logrank法做差异检验 ,Cox回归法统计影响局部控制率 (LC)和总生存率 (OS)的预后因素。结果 :中位随访时间 5 7个月 (5个月～ 114个月 )。 5年总生存率分别为 44 4%。 5年局部控制率为 44 3 % 19例在随访过程中出现局部复发 (10例为原发部位复发 ,8例为颈部淋巴结复发 ,1例因失访复发部位不详 ) ,16例出现远处转移。结论 :T N分期 ,病理类型 ,疗终时肿瘤有无残存是影响软腭癌放射治疗疗效的主要因素。

Objective To analyze the prognostic factors of soft palate cancer treated with definitive radiotheraphy Methods from 1990～1999,90 patients(63 male,27 female),12 no-differentiated carcinoma,22 poorly differentiated carcinoma,48 squama,8 adenocarcinoma they were treated with radiotheraphy to a dose of 60～70GY Loco-regional control(LC)and overall survival(OS)rates were estimated by the Kaplan-Meier method Logrank and Cox regression analyses were used to identify the prognostic factors Results The median follow-up time was 57months(range,5～114 months) The 3-and 5-years OS rates were and The 5-years LC rate was 31 patients developed recurrent disease(18l ocally,12 in cervical lymph nodes,1 lost to follow-up),15 patientshavetransferedto distans Conclusions Our analysis shows that the stage of desease,typeofpathologeandtumorresidual after radiotheraphy may have influence on the prognosis of soft palate cancer treated with definitive radiotherophy