摘要
目的 观察抗纤颗粒治疗大鼠肝纤维化的疗效并探讨其作用机理。方法 采用二甲基亚硝胺诱导的大鼠肝纤维化模型 ,观察抗纤颗粒治疗前后 TNF- α、γ- IFN含量的变化。结果 抗纤颗粒治疗组较模型组 TNF- α含量下降 (P<0 .0 5 ) ,γ- IFN含量上升 (P<0 .0 5 )。结论 抗纤颗粒对二甲基亚硝胺诱导的大鼠肝纤维化有治疗作用 ,其部分机理为通过调节细胞因子的含量 ,而达到抗肝纤维化的目的。
Objective To investigate the therapeutic effect of Kangxiankeli(KXKL) on experimental liver fibrosis and to reveal its mechanism. Methods By establishing models of dimethylnitrosamine (DMN)-induced liver fibrosis in rat, we observed the effect of KXKL on content of TNF-α and γ-IFN. Results There was a decline of serum TNF-α and a increase of serum γ-IFN in KXKL group, compared to those of the DMN group (P<0.05). Conclusions Our results suggest KXKL has therapeutic effect in DMN-induced rat liver fibrosis ,probably by regulating the cytokine contents of TNF-α and γ-IFN.
出处
《西部医学》
2003年第4期302-303,共2页
Medical Journal of West China
