乳腺癌类固醇激素受体的检测在内分泌治疗中的价值

CORREIATION OF STEROID-HORMONE RECEPTERS WITH ESTIMATION TO THEOCRINOLOGICAL THERAPY IN BREAST CARCINOMA

用免疫组化技术对５５例乳腺导管浸润癌类固醇激素受体进行了检测，结果５年内的导管浸润癌蜡块，其ＥＲ，ＰＲ，ＡＲ阳性率分别为７３．５％，６１．８％，６７．６％；保存５年以上蜡块组三者阳性率分别为５２．４％，３８．１％，４７．６％，阳性强度下降，但两组差异无显著性（Ｐ＞０．０５）。ＳＲ阳性颗粒在５年内乳腺癌组织切片中多为核浆型及核为主型，而５年以上组浆膜型增多。提示，随着标本保存时间延长，受体蛋白质成分有所减少，阳性率及阳性强度下降，不利于临床内分泌疗效的判断。

Immuno-biocheical technique was used to assy the steroid-hormone receptors(SR)of invasive ductal breast carcinoma,and the authors found that the positive rate of estrogen recepted(ER),progesterone recepter(RP),androgen recepter(AR)of near 5 year breast carcinoma differentiately was 73.5%,61.8%,67.6%,while the positive rate of ER,PR,AR of over 5 year(contain 10 year)breast carcinoma diferentiately was 52.4%,38.1%,47.6% and the positive intense was much weaker than the former group.But there was no significant greatly(P>0.05).The positive granule of the SR in over 5 year group increased in form of plasam-membrane in carcinoma cells.This showed that the components of the SR losed as the time of the stored breast carcinoma become longer and it was inconvient to the clinians to estimate the effect of endocrinological therapy,because the higher the postive rate of SR are the better result of endocrinological therapy become.