摘要
本文对出生后接种不同剂量乙肝血源疫苗的272名婴儿进行了3-5年的效果随访观察。结果表明,接种3、4、5年后,抗-HBs阳性率仍分别保持在90.5%、82.3%和73.2%,HBsAg阳性率分别为2.8%、3.1%和4.2%。3年后抗-HBs阳性率逐年下降,P/N值>50者以接种后3年为多,<50者以5年为多,3年后也呈下降趋势。随访结果说明,接种10μg×4、5μg×4及2.5μg×4剂量的乙肝疫苗具有阻断母婴乙肝病毒传播的效果。鉴于P/N值及抗-HBs阳性率在接种后3年开始下降,建议接种后3年应进行一次加强接种。
Long-term efficacy was investigated by following up 272 babies who had received various doses plasma-derived HB-vaccine. The result showed that the anti-HBs positive rates in third year, fourth year and fifth year was 90.5%,82.3%,73.2%, respectively,and the HBsAg positive rates durin'g those years was 2.8%,3.1%,4.2%, respectively.The positive rate of anti-HBs began to decrease year after year since the 3rd year after vaccination. The babies that P/N value was higher than fifty came down as dominant factor since the third year after vaccination. However, the babies that P/N value was lower than fifty came down as dominant factor since the fifth year after vaccination. Both the former and the latter were tending to decline three years after vaccination. these results indicate that 4×10mcg, 4×5mncg, 4×2.5mcg hepatitis B vaccine have long-term efficacy to prevent vertical transmission of hepatitis B virus.in view of P/N value and positive rate of anti-HBs began to decline three years after vaccination. It is suggested that a booster should be done in the third year after vaccination.
出处
《微生物学免疫学进展》
1994年第3期39-42,共4页
Progress In Microbiology and Immunology
关键词
乙型肝炎
疫苗
病毒
母婴传播
HB-vaccine prevent HBV transmission from HBsSAg+ mothers to newborns HBV mark