不同剂量乙肝疫苗阻断乙型肝炎病毒母婴传播的远期效果观察

Long-term efficacy by following up babies various dose Plasma-derived HB-vaccine

本文对出生后接种不同剂量乙肝血源疫苗的２７２名婴儿进行了３－５年的效果随访观察。结果表明，接种３、４、５年后，抗－ＨＢｓ阳性率仍分别保持在９０．５％、８２．３％和７３．２％，ＨＢｓＡｇ阳性率分别为２．８％、３．１％和４．２％。３年后抗－ＨＢｓ阳性率逐年下降，Ｐ／Ｎ值＞５０者以接种后３年为多，＜５０者以５年为多，３年后也呈下降趋势。随访结果说明，接种１０μｇ×４、５μｇ×４及２．５μｇ×４剂量的乙肝疫苗具有阻断母婴乙肝病毒传播的效果。鉴于Ｐ／Ｎ值及抗－ＨＢｓ阳性率在接种后３年开始下降，建议接种后３年应进行一次加强接种。

Long-term efficacy was investigated by following up 272 babies who had received various doses plasma-derived HB-vaccine. The result showed that the anti-HBs positive rates in third year, fourth year and fifth year was 90.5%,82.3%,73.2%, respectively,and the HBsAg positive rates durin'g those years was 2.8%,3.1%,4.2%, respectively.The positive rate of anti-HBs began to decrease year after year since the 3rd year after vaccination. The babies that P/N value was higher than fifty came down as dominant factor since the third year after vaccination. However, the babies that P/N value was lower than fifty came down as dominant factor since the fifth year after vaccination. Both the former and the latter were tending to decline three years after vaccination. these results indicate that 4×10mcg, 4×5mncg, 4×2.5mcg hepatitis B vaccine have long-term efficacy to prevent vertical transmission of hepatitis B virus.in view of P/N value and positive rate of anti-HBs began to decline three years after vaccination. It is suggested that a booster should be done in the third year after vaccination.