新生儿接种小剂量乙肝疫苗后3-5年随访观察

The Follow-up Observation for 3-5 Years on Newborns After lnoculation of Small Dosage of HB-Vaccine

本文对９３８例初生婴儿接种小剂量（１０ｕｇ×３）乙肝疫苗后３－５年的预防效果进行了随访观察，并以２５３例初生儿未接种疫苗者作为对照，结果表明，接种组３－５年后抗－ＨＢｓ阳性率显著高于对照组，ＨＢｓＡｇ阳性率则较对照组显著为低。感染保护率８６．７％。结果还表明，接种乙肝疫苗３年后加强１次，比不加强者Ｐ／Ｎ均值显著增高。文章认为初生儿接种小剂量乙肝疫苗有长期免疫效果；接种后３年加强接种１次，可保持较高免疫力。

The effect of plasma-derived HB-vaccine was studied for 3-5 years by follow-up 938 infants who had received three doses 10μ9 at intervals 0, 1 , 6 months and with a control group composed of 253 infants who hadn t received the vaccine The results indicated that the anti-HBs positive rate of the group in 3-5 years after vaccination was significantly higher than that of the control group. The HBsAg positive rate of the latter was significantly higher than that of the former. The protective rate of infection was 86.7%.The results also indicated that P/N value of the group that booster dose was done three years after vaccination was significantly higher than that of the group that booster wasn t done The observation showed tha three doses 10μg of plasma-derived HB-vaccine for infants could provide a long-term efficacy and the booster dose might maintain the efficacy of immunity after vaccination.